Animal and organoid models of liver fibrosis
Y Bao, L Wang, H Pan, T Zhang, Y Chen, S Xu… - Frontiers in …, 2021 - frontiersin.org
Liver fibrosis refers to the process underlying the development of chronic liver diseases,
wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive …
wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive …
Astaxanthin activated the Nrf2/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury
X Cai, S Hua, J Deng, Z Du, D Zhang… - … Applied Materials & …, 2022 - ACS Publications
Acetaminophen (APAP)-induced liver injury (AILI) is a common liver disease in clinical
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …
An update on animal models of liver fibrosis
ST Wu, XX Wang, WB **ng, FY Li, M Liang, KS Li… - Frontiers in …, 2023 - frontiersin.org
The development of liver fibrosis primarily determines quality of life as well as prognosis.
Animal models are often used to model and understand the underlying mechanisms of …
Animal models are often used to model and understand the underlying mechanisms of …
Metabolic profiling of thymic epithelial tumors hints to a strong Warburg effect, glutaminolysis and precarious redox homeostasis as potential therapeutic targets
Simple Summary Thymomas and thymic carcinomas (TCs) are malignant thymic epithelial
tumors (TETs) with poor outcome, if non-resectable. Metabolic signatures of TETs have not …
tumors (TETs) with poor outcome, if non-resectable. Metabolic signatures of TETs have not …
The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets
L Gong, L Liao, X Dai, X Xue, C Peng, Y Li - Toxicology Letters, 2021 - Elsevier
Acetaminophen (APAP), one of the most widely used antipyretic and analgesic drugs,
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …
The potential protective effect of curcumin and α-lipoic acid on N-(4-Hydroxyphenyl) acetamide-induced hepatotoxicity through downregulation of α-SMA and collagen …
A Alhusain, L Fadda, W Sarawi, H Alomar… - Dose …, 2022 - journals.sagepub.com
Background and objectives N-(4-hydroxyphenyl) acetamide (NHPA) is the most commonly
used analgesic and antipyretic agent worldwide; however, it remains the leading cause of …
used analgesic and antipyretic agent worldwide; however, it remains the leading cause of …
[PDF][PDF] Hepatotoxicity-Induced by the therapeutic dose of acetaminophen and the ameliorative effect of oral co-administration of selenium/Tribulus terrestris extract in …
AA Al-Doaiss - Int. j. morphol, 2020 - researchgate.net
Over dose or long-term clinical use of therapeutic doses of acetaminophen (APAP) causes
hepatotoxicity. Various strategies attempted to ameliorate APAP-hepatotoxicity have been …
hepatotoxicity. Various strategies attempted to ameliorate APAP-hepatotoxicity have been …
Eucalyptus oil abrogated liver damage, oxidant/antioxidant imbalance, inflammation and apoptosis stimulated by acetaminophen in rats: biochemical, molecular and …
NW Esmail, SM El-sheikh, RMS Korany… - Journal of Advanced …, 2024 - advetresearch.com
Acetaminophen is an analgesic antipyretic commonly used. Hepatotoxicity is one of the most
common obstacles to acetaminophen therapy. Eucalyptus oil is an antioxidant with potent …
common obstacles to acetaminophen therapy. Eucalyptus oil is an antioxidant with potent …
Pharmacologically Induced Animal Models for Various Diseases
S Ramesh, L Kalaiselvi, MR Srinivasan - Animal Models in Research …, 2024 - Springer
Despite the advances in genetics and genetic models, drug-induced models of animal
disease are still popular for the ease of model development. Over the years, these models …
disease are still popular for the ease of model development. Over the years, these models …
Pericrine regulation of physiological and pathological liver functions via hepatic stellate cell-derived RSPO3
G Wang - 2025 - archiv.ub.uni-heidelberg.de
The liver exerts multiple essential functions of our body, such as digestion, detoxification,
biosynthesis, and storage of various nutrients. These functions are executed via a complex …
biosynthesis, and storage of various nutrients. These functions are executed via a complex …