Due to postmortem DNA degradation and microbial colonization, most ancient genomes
have low depth of coverage, hindering genotype calling. Genotype imputation can improve …

Signatures of positive selection in the genome are a characteristic mark of adaptation that
can reveal an ongoing, recent, or ancient response to environmental change throughout the …

Genetic association data from national biobanks and large-scale association studies have
provided new prospects for understanding the genetic evolution of complex traits and …

Degraded DNA is used to answer questions in the fields of ancient DNA (aDNA) and
forensic genetics. While aDNA studies typically center around human evolution and past …

Historical genomes can provide important insights into recent genomic changes in horses,
especially the development of modern breeds. In this study, we characterized 8.7 million …

Abstract Motivation Human ancient DNA (aDNA) studies have surged in recent years,
revolutionizing the study of the human past. Typically, aDNA is preserved poorly, making …

We investigate alternative strategies against reference bias and postmortem damage in low
coverage paleogenomes. Compared to alignment to the linear reference genome, we show …

Low-coverage imputation is becoming ever more present in ancient DNA (aDNA) studies.
Imputation pipelines commonly used for present-day genomes have been shown to yield …

Ancient DNA can directly reveal the contribution of natural selection to human genomic
variation. However, while the analysis of ancient DNA has been successful at identifying …

Motivation Genotype imputation has the potential to increase the amount of information that
can be gained from the often limited biological material available in ancient samples. As …