Many publicly available data repositories and resources have been developed to support
protein-related information management, data-driven hypothesis generation, and biological …

Variations and similarities in our individual genomes are part of our history, our heritage,
and our identity. Some human genomic variants are associated with common traits such as …

The rate at which nonsynonymous single nucleotide polymorphisms (ns SNP s) are being
identified in the human genome is increasing dramatically owing to advances in whole …

Genome-wide association studies (GWASs), now as a routine approach to study single-
nucleotide polymorphism (SNP)-trait association, have uncovered over ten thousand …

In cancer genomics, recurrence of mutations in independent tumor samples is a strong
indicator of functional impact. However, rare functional mutations can escape detection by …

The role of plasma membrane transporters in cancer is receiving increasing attention in
recent years. Several transporters for essential nutrients are up-regulated in cancer and …

Disruption of the establishment of left-right (LR) asymmetry leads to situs anomalies ranging
from situs inversus totalis (SIT) to situs ambiguus (heterotaxy). The genetic causes of …

Coenzyme Q (CoQ or ubiquinone) serves as an essential redox-active lipid in respiratory
electron and proton transport during cellular energy metabolism. CoQ also functions as a …

Disease-causing aberrations in the normal function of a gene define that gene as a disease
gene. Proving a causal link between a gene and a disease experimentally is expensive and …

An international consortium released the first draft sequence of the human genome 10 years
ago. Although the analysis of this data has suggested the genetic underpinnings of many …