Mesenchymal stem/stromal cells in cancer therapy

T Lan, M Luo, X Wei - Journal of Hematology & Oncology, 2021 - Springer
The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone
marrow in 1976, have been identified in nearly all tissues of human body now. The …

Therapeutic potential of mesenchymal stem cells for cancer therapy

A Hmadcha, A Martin-Montalvo, BR Gauthier… - … in bioengineering and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for
regenerative medicine. A large number of studies have shown the beneficial effects of MSC …

Ethical and safety issues of stem cell-based therapy

V Volarevic, BS Markovic, M Gazdic… - … journal of medical …, 2018 - pmc.ncbi.nlm.nih.gov
Results obtained from completed and on-going clinical studies indicate huge therapeutic
potential of stem cell-based therapy in the treatment of degenerative, autoimmune and …

Mesenchymal stem cells: key players in cancer progression

SM Ridge, FJ Sullivan, SA Glynn - Molecular cancer, 2017 - Springer
Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …

The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment

W Li, Q Liu, J Shi, X Xu, J Xu - Frontiers in immunology, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional
differentiation potential and strong immunomodulatory capacity. MSCs have been widely …

Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment

N Ghasemi Darestani, AI Gilmanova… - Cell Communication and …, 2023 - Springer
Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no
damage to normal cells in the process. Because of their specific features, such as, the ability …

Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells

JK Lee, SR Park, BK Jung, YK Jeon, YS Lee, MK Kim… - PloS one, 2013 - journals.plos.org
Exosomes are small membrane vesicles released by a variety of cell types. Exosomes
contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they …

A new approach for loading anticancer drugs into mesenchymal stem cell-derived exosome mimetics for cancer therapy

S Kalimuthu, P Gangadaran, RL Rajendran… - Frontiers in …, 2018 - frontiersin.org
Exosomes derived from mesenchymal stem cells (MSCs) have been evaluated for their
potential to be used as drug delivery vehicles. Synthetically personalized exosome mimetics …

Mesenchymal stem cells in health and disease

A Uccelli, L Moretta, V Pistoia - Nature reviews immunology, 2008 - nature.com
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …