The heat shock response: life on the verge of death
K Richter, M Haslbeck, J Buchner - Molecular cell, 2010 - cell.com
Organisms must survive a variety of stressful conditions, including sudden temperature
increases that damage important cellular structures and interfere with essential functions. In …
increases that damage important cellular structures and interfere with essential functions. In …
The N‐end rule pathway and regulation by proteolysis
A Varshavsky - Protein science, 2011 - Wiley Online Library
The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
The N-end rule pathway
The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …
proteins are recognized by recognition components (N-recognins) as essential components …
Retapamulin-assisted ribosome profiling reveals the alternative bacterial proteome
The use of alternative translation initiation sites enables production of more than one protein
from a single gene, thereby expanding the cellular proteome. Although several such …
from a single gene, thereby expanding the cellular proteome. Although several such …
The ins and outs of Bacillus proteases: activities, functions and commercial significance
Because the majority of bacterial species divide by binary fission, and do not have
distinguishable somatic and germline cells, they could be considered to be immortal …
distinguishable somatic and germline cells, they could be considered to be immortal …
Tying up loose ends: the N-degron and C-degron pathways of protein degradation
RT Timms, I Koren - Biochemical Society Transactions, 2020 - portlandpress.com
Selective protein degradation by the ubiquitin-proteasome system (UPS) is thought to be
governed primarily by the recognition of specific motifs—degrons—present in substrate …
governed primarily by the recognition of specific motifs—degrons—present in substrate …
Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences
A mRNA's translation rate is controlled by several sequence determinants, including the
presence of RNA structures within the N-terminal regions of its coding sequences. However …
presence of RNA structures within the N-terminal regions of its coding sequences. However …
The N-end rule pathway: emerging functions and molecular principles of substrate recognition
SM Sriram, BY Kim, YT Kwon - Nature reviews Molecular cell biology, 2011 - nature.com
The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue
and its post-translational modification. Since its discovery 25 years ago, the pathway …
and its post-translational modification. Since its discovery 25 years ago, the pathway …
[HTML][HTML] Processing peptidases in mitochondria and chloroplasts
Most of the mitochondrial and chloroplastic proteins are nuclear encoded and synthesized in
the cytosol as precursor proteins with N-terminal extensions called targeting peptides …
the cytosol as precursor proteins with N-terminal extensions called targeting peptides …
Processing of mitochondrial presequences
D Mossmann, C Meisinger, FN Vögtle - Biochimica et Biophysica Acta (BBA …, 2012 - Elsevier
Mitochondrial proteins are synthesized as precursor proteins on either cytosolic or
mitochondrial ribosomes. The synthesized precursors from both translation origins possess …
mitochondrial ribosomes. The synthesized precursors from both translation origins possess …