Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …

Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …

Hepatocellular carcinoma (HCC) is a significant global health challenge. The activation of
autophagy plays an essential role in promoting the proliferation and survival of cancer cells …

MicroRNAs can exhibit opposite functions in different tumors. MiR-31 is a representative
example as it can not only enhance tumor development and progression in pancreatic …

Acetylation and deacetylation of histone and several non-histone proteins are the two
important processes amongst the different modes of epigenetic modulation that are involved …

Abstract Mammalian sirtuin 1 (SIRT1) has connected to an ever widening circle of activities
that encompass cellular stress resistance, energy metabolism and tumorigenesis. However …

MicroRNA-31 (miR-31) is among the most frequently altered microRNAs in human cancers
and altered expression of miR-31 has been detected in a large variety of tumor types, but the …

Controlled release of medications remains the most convenient way to deliver drugs. In this
study, we precipitated gold nanoparticles with quercetin. We loaded gold-quercetin into poly …

Hepatocellular carcinoma (HCC) is a major contributor to the global cancer burden. Given
the current limited options to treat advanced HCC, understanding the molecular basis of …

Histone deacetylases (HDACs) are known to play a central role in the regulation of several
cellular properties interlinked with the development and progression of cancer. Recently …