Artificial intelligence in histopathology: enhancing cancer research and clinical oncology

A Shmatko, N Ghaffari Laleh, M Gerstung, JN Kather - Nature cancer, 2022 - nature.com
Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative
information from digital histopathology images. AI is expected to reduce workload for human …

Deep learning in histopathology: the path to the clinic

J Van der Laak, G Litjens, F Ciompi - Nature medicine, 2021 - nature.com
Abstract Machine learning techniques have great potential to improve medical diagnostics,
offering ways to improve accuracy, reproducibility and speed, and to ease workloads for …

Scaling vision transformers to gigapixel images via hierarchical self-supervised learning

RJ Chen, C Chen, Y Li, TY Chen… - Proceedings of the …, 2022 - openaccess.thecvf.com
Abstract Vision Transformers (ViTs) and their multi-scale and hierarchical variations have
been successful at capturing image representations but their use has been generally …

Towards a general-purpose foundation model for computational pathology

RJ Chen, T Ding, MY Lu, DFK Williamson, G Jaume… - Nature Medicine, 2024 - nature.com
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks,
requiring the objective characterization of histopathological entities from whole-slide images …

Deep learning-enabled medical computer vision

A Esteva, K Chou, S Yeung, N Naik, A Madani… - NPJ digital …, 2021 - nature.com
A decade of unprecedented progress in artificial intelligence (AI) has demonstrated the
potential for many fields—including medicine—to benefit from the insights that AI techniques …

Deep learning in cancer pathology: a new generation of clinical biomarkers

A Echle, NT Rindtorff, TJ Brinker, T Luedde… - British journal of …, 2021 - nature.com
Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers.
However, the growing number of these complex biomarkers tends to increase the cost and …

Multimodal co-attention transformer for survival prediction in gigapixel whole slide images

RJ Chen, MY Lu, WH Weng, TY Chen… - Proceedings of the …, 2021 - openaccess.thecvf.com
Survival outcome prediction is a challenging weakly-supervised and ordinal regression task
in computational pathology that involves modeling complex interactions within the tumor …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Review of deep learning: concepts, CNN architectures, challenges, applications, future directions

L Alzubaidi, J Zhang, AJ Humaidi, A Al-Dujaili… - Journal of big Data, 2021 - Springer
In the last few years, the deep learning (DL) computing paradigm has been deemed the
Gold Standard in the machine learning (ML) community. Moreover, it has gradually become …

Whole slide images based cancer survival prediction using attention guided deep multiple instance learning networks

J Yao, X Zhu, J Jonnagaddala, N Hawkins… - Medical Image Analysis, 2020 - Elsevier
Traditional image-based survival prediction models rely on discriminative patch labeling
which make those methods not scalable to extend to large datasets. Recent studies have …