Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans
ABSTRACT In June 2017, the National Institute of Allergy and Infectious Diseases, part of
the National Institutes of Health, organized a workshop entitled “Pharmacokinetics …
the National Institutes of Health, organized a workshop entitled “Pharmacokinetics …
Bacteriocin-antimicrobial synergy: a medical and food perspective
The continuing emergence of multi-drug resistant pathogens has sparked an interest in
seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such …
seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such …
International consensus guidelines for the optimal use of the polymyxins: endorsed by the American college of clinical pharmacy (ACCP), European society of clinical …
The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …
1950s and thus did not undergo contemporary drug development procedures. Their clinical …
Agents of last resort: polymyxin resistance
The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …
interesting history. Originally introduced in the 1950s for the treatment of infections due to …
Limitations of antibiotic MIC-based PK-PD metrics: looking back to move forward
Within a few years after the first successful clinical use of penicillin, investigations were
conducted in animal infection models to explore a range of factors that were considered …
conducted in animal infection models to explore a range of factors that were considered …
Polymyxin combination therapy for multidrug-resistant, extensively-drug resistant, and difficult-to-treat drug-resistant gram-negative infections: is it superior to …
A Ardebili, A Izanloo, M Rastegar - Expert Review of Anti-infective …, 2023 - Taylor & Francis
Introduction The increasing prevalence of infections with multidrug-resistant (MDR),
extensively-drug resistant (XDR) or difficult-to-treat drug resistant (DTR) Gram-negative …
extensively-drug resistant (XDR) or difficult-to-treat drug resistant (DTR) Gram-negative …
Combination therapy for carbapenem-resistant Gram-negative bacteria
The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …
Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling
Bacterial resistance is among the most serious threats to human health globally, and many
bacterial isolates have emerged that are resistant to all antibiotics in monotherapy …
bacterial isolates have emerged that are resistant to all antibiotics in monotherapy …
Mechanism of action of isopropoxy benzene guanidine against multidrug-resistant pathogens
J Li, X Zhang, N Han, P Wan, F Zhao, T Xu… - Microbiology …, 2023 - Am Soc Microbiol
The increasing emergence of antibiotic resistance is an urgent threat to global health care;
thus, there is a need for new therapeutics. Guanidine is the preferred functional group for …
thus, there is a need for new therapeutics. Guanidine is the preferred functional group for …
Resveratrol enhances the antimicrobial effect of polymyxin B on Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance
L Liu, J Yu, X Shen, X Cao, Q Zhan, Y Guo, F Yu - BMC microbiology, 2020 - Springer
Abstract Background Multidrug resistant (MDR) Gram-negative bacterial infections are a
serious threat to human health due to the lack of effective treatments. In this study, we …
serious threat to human health due to the lack of effective treatments. In this study, we …