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Comprehensive review in current developments of benzimidazole‐based medicinal chemistry
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …
Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
S Tahlan, S Kumar, B Narasimhan - BMC chemistry, 2019 - Springer
Heterocyclic compounds are inevitable in a numerous part of life sciences. These molecules
perform various noteworthy functions in nature, medication and innovation. Nitrogen …
perform various noteworthy functions in nature, medication and innovation. Nitrogen …
Mannich bases in medicinal chemistry and drug design
G Roman - European journal of medicinal chemistry, 2015 - Elsevier
The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …
compounds that are generated from various substrates through the introduction of an …
Quantum chemical study of some basic organic compounds as the corrosion inhibitors
The corrosion inhibitor activities of 10 molecules (Benzene (C1), Phenol (C2), Toluene (C3),
Benzoic acid (C4), Acetophenone (C5), Chlorobenzene (C6), Bromobenzene (C7) …
Benzoic acid (C4), Acetophenone (C5), Chlorobenzene (C6), Bromobenzene (C7) …
Benzimidazole: A promising pharmacophore
The aim of this review is to provide an overview on diverse pharmacological activities of the
benzimidazole moiety. This review highlights recent reports of antimicrobial, anticancer …
benzimidazole moiety. This review highlights recent reports of antimicrobial, anticancer …
Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases
The tri-component synthesis of novel chiral benzimidazole Mannich bases, by reaction
between benzimidazole, aqueous 30% formaldehyde and an amine, the biological …
between benzimidazole, aqueous 30% formaldehyde and an amine, the biological …
Revealing the inhibition mechanism of RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by remdesivir and nucleotide analogues: A molecular dynamics …
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …
Computer-aided discovery of bis-indole derivatives as multi-target drugs against cancer and bacterial infections: DFT, docking, virtual screening, and molecular …
Recently, more complex diseases of seemingly incurable pathology have demonstrated the
need for potent and multi-target drugs. Specific to many cancers and bacterial diseases …
need for potent and multi-target drugs. Specific to many cancers and bacterial diseases …
Molecular, Electronic, Nonlinear Optical and Spectroscopic Analysis of Heterocyclic 3-Substituted-4-(3-methyl-2-thienylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol …
M Beytur, I Avinca - Heterocyclic Communications, 2021 - degruyter.com
In the present study, 3-p-methoxybenzyl/m-chlorobenzyl/phenyl-4-(3-methyl-2-
thienylmethyleneamino)-4, 5-dihydro-1 H-1, 2, 4-triazol-5-ones were obtained from the …
thienylmethyleneamino)-4, 5-dihydro-1 H-1, 2, 4-triazol-5-ones were obtained from the …
Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole–benzimidazole derivatives as potent Aurora A/B kinase inhibitors
Novel pyrazole–benzimidazole derivatives have been designed and synthesized. The entire
target compounds were determined against cancer cell lines U937, K562, A549, LoVo and …
target compounds were determined against cancer cell lines U937, K562, A549, LoVo and …