Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

S Tahlan, S Kumar, B Narasimhan - BMC chemistry, 2019 - Springer
Heterocyclic compounds are inevitable in a numerous part of life sciences. These molecules
perform various noteworthy functions in nature, medication and innovation. Nitrogen …

Mannich bases in medicinal chemistry and drug design

G Roman - European journal of medicinal chemistry, 2015 - Elsevier
The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …

Quantum chemical study of some basic organic compounds as the corrosion inhibitors

L Ahmed, N Bulut, O Kaygılı, R Omer - Journal of Physical …, 2023 - dergipark.org.tr
The corrosion inhibitor activities of 10 molecules (Benzene (C1), Phenol (C2), Toluene (C3),
Benzoic acid (C4), Acetophenone (C5), Chlorobenzene (C6), Bromobenzene (C7) …

Benzimidazole: A promising pharmacophore

K Shah, S Chhabra, SK Shrivastava… - Medicinal Chemistry …, 2013 - Springer
The aim of this review is to provide an overview on diverse pharmacological activities of the
benzimidazole moiety. This review highlights recent reports of antimicrobial, anticancer …

Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases

M Marinescu, LO Cinteză, GI Marton, MC Chifiriuc… - BMC chemistry, 2020 - Springer
The tri-component synthesis of novel chiral benzimidazole Mannich bases, by reaction
between benzimidazole, aqueous 30% formaldehyde and an amine, the biological …

Revealing the inhibition mechanism of RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by remdesivir and nucleotide analogues: A molecular dynamics …

PD Wakchaure, S Ghosh… - The Journal of Physical …, 2020 - ACS Publications
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …

Computer-aided discovery of bis-indole derivatives as multi-target drugs against cancer and bacterial infections: DFT, docking, virtual screening, and molecular …

PSS Gupta, HR Bhat, S Biswal, MK Rana - Journal of Molecular Liquids, 2020 - Elsevier
Recently, more complex diseases of seemingly incurable pathology have demonstrated the
need for potent and multi-target drugs. Specific to many cancers and bacterial diseases …

Molecular, Electronic, Nonlinear Optical and Spectroscopic Analysis of Heterocyclic 3-Substituted-4-(3-methyl-2-thienylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol …

M Beytur, I Avinca - Heterocyclic Communications, 2021 - degruyter.com
In the present study, 3-p-methoxybenzyl/m-chlorobenzyl/phenyl-4-(3-methyl-2-
thienylmethyleneamino)-4, 5-dihydro-1 H-1, 2, 4-triazol-5-ones were obtained from the …

Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole–benzimidazole derivatives as potent Aurora A/B kinase inhibitors

Y Zheng, M Zheng, X Ling, Y Liu, Y Xue, L An… - Bioorganic & Medicinal …, 2013 - Elsevier
Novel pyrazole–benzimidazole derivatives have been designed and synthesized. The entire
target compounds were determined against cancer cell lines U937, K562, A549, LoVo and …