Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

The function of mitochondrial fusion and fission is one of the important factors causing
ischemia-reperfusion (I/R) injury in diabetic myocardium. Aldehyde dehydrogenase 2 …

Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and
aldehydic load is a hallmark of heart failure. Recently, different research groups have …

Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

Lipids can go through lipid peroxidation, an endogenous chain reaction that consists in the
oxidative degradation of lipids leading to the generation of a wide variety of highly reactive …

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases,
including multiple cardiovascular disorders. However, translation of ROS scavengers …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …