Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway
health and disease. Mucins are highly glycosylated macromolecules (≥ 50% carbohydrate …

Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

Considerable advances have been made in recent years in our understanding of the
biochemistry of mucin-type glycoproteins. This class of compounds is characterized mainly …

A human bronchial xenograft model was used to characterize the molecular basis for the
previously described defect in bacterial killing that is present in the cystic fibrosis (CF) lung …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Individuals with cystic fibrosis have abbreviated life spans primarily due to chronic airway
infection. A limited number of types of organisms are responsible for these infections, with …

Cystic fibrosis (CF) is an autosomal recessive genetic disorder that is characterized by
recurrent and chronic infections of the lung predominantly by the opportunistic pathogens …

Grubb, Barbara R., and Richard C. Boucher. Pathophysiology of Gene-Targeted Mouse
Models for Cystic Fibrosis. Physiol. Rev. 79, Suppl.: S193–S214, 1999.—Mutations in the …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …