Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions

S Vatansever, A Schlessinger, D Wacker… - Medicinal research …, 2021 - Wiley Online Library
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, develo** drugs for central nervous system (CNS) disorders remains the most …

[HTML][HTML] Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses

E Drummond, W McCulloch, GM Knudsen… - Neuroscience & …, 2022 - Elsevier
Clinical research into serotonergic psychedelics is expanding rapidly, showing promising
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …

An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)

AM Avila, I Bebenek, JA Bonzo, T Bourcier… - Regulatory Toxicology …, 2020 - Elsevier
Nonclinical testing of human pharmaceuticals is conducted to assess the safety of
compounds to be studied in human clinical trials and for marketing of new drugs. Although …

Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments

G Soleimani, MA Nitsche, TO Bergmann… - Translational …, 2023 - nature.com
One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …

Current challenges in translational and clinical fMRI and future directions

K Specht - Frontiers in psychiatry, 2020 - frontiersin.org
Translational neuroscience is an important field that brings together clinical praxis with
neuroscience methods. In this review article, the focus will be on functional neuroimaging …

Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results

S Linguiti, JW Vogel, VJ Sydnor, A Pines… - Neuroscience & …, 2023 - Elsevier
Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study
the acute impact of psychedelics on the human brain. While fMRI is a promising tool for …

Head trauma in sports–clinical characteristics, epidemiology and biomarkers

H Zetterberg, B Winblad, C Bernick… - Journal of internal …, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is clinically divided into a spectrum of severities, with mild TBI
being the least severe form and a frequent occurrence in contact sports, such as ice hockey …

The use of functional magnetic resonance imaging (fMRI) in clinical trials and experimental research studies for depression

V Kotoula, JW Evans, CE Punturieri… - Frontiers in …, 2023 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that can be used
to examine neural responses with and without the use of a functional task. Indeed, fMRI has …

Cortical connectivity moderators of antidepressant vs placebo treatment response in major depressive disorder: secondary analysis of a randomized clinical trial

CE Rolle, GA Fonzo, W Wu, R Toll, MK Jha… - JAMA …, 2020 - jamanetwork.com
Importance Despite the widespread awareness of functional magnetic resonance imaging
findings suggesting a role for cortical connectivity networks in treatment selection for major …

A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus

H Ekhtiari, M Zare-Bidoky, A Sangchooli, AC Janes… - Nature …, 2022 - nature.com
Cue reactivity is one of the most frequently used paradigms in functional magnetic
resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have …