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Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, develo** drugs for central nervous system (CNS) disorders remains the most …
However, develo** drugs for central nervous system (CNS) disorders remains the most …
[HTML][HTML] Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses
Clinical research into serotonergic psychedelics is expanding rapidly, showing promising
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)
AM Avila, I Bebenek, JA Bonzo, T Bourcier… - Regulatory Toxicology …, 2020 - Elsevier
Nonclinical testing of human pharmaceuticals is conducted to assess the safety of
compounds to be studied in human clinical trials and for marketing of new drugs. Although …
compounds to be studied in human clinical trials and for marketing of new drugs. Although …
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments
One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …
Current challenges in translational and clinical fMRI and future directions
K Specht - Frontiers in psychiatry, 2020 - frontiersin.org
Translational neuroscience is an important field that brings together clinical praxis with
neuroscience methods. In this review article, the focus will be on functional neuroimaging …
neuroscience methods. In this review article, the focus will be on functional neuroimaging …
Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results
Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study
the acute impact of psychedelics on the human brain. While fMRI is a promising tool for …
the acute impact of psychedelics on the human brain. While fMRI is a promising tool for …
Head trauma in sports–clinical characteristics, epidemiology and biomarkers
Traumatic brain injury (TBI) is clinically divided into a spectrum of severities, with mild TBI
being the least severe form and a frequent occurrence in contact sports, such as ice hockey …
being the least severe form and a frequent occurrence in contact sports, such as ice hockey …
The use of functional magnetic resonance imaging (fMRI) in clinical trials and experimental research studies for depression
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that can be used
to examine neural responses with and without the use of a functional task. Indeed, fMRI has …
to examine neural responses with and without the use of a functional task. Indeed, fMRI has …
Cortical connectivity moderators of antidepressant vs placebo treatment response in major depressive disorder: secondary analysis of a randomized clinical trial
Importance Despite the widespread awareness of functional magnetic resonance imaging
findings suggesting a role for cortical connectivity networks in treatment selection for major …
findings suggesting a role for cortical connectivity networks in treatment selection for major …
A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus
Cue reactivity is one of the most frequently used paradigms in functional magnetic
resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have …
resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have …