Leishmaniasis in humans: drug or vaccine therapy?

M Ghorbani, R Farhoudi - Drug design, development and therapy, 2017 - Taylor & Francis
Leishmania is an obligate intracellular pathogen that invades phagocytic host cells.
Approximately 30 different species of Phlebotomine sand flies can transmit this parasite …

[HTML][HTML] Status of vaccine research and development of vaccines for leishmaniasis

PM Gillespie, CM Beaumier, U Strych, T Hayward… - Vaccine, 2016 - Elsevier
A number of leishmaniasis vaccine candidates are at various stages of pre-clinical and
clinical development. Leishmaniasis is a vector-borne neglected tropical disease (NTD) …

Current visceral leishmaniasis research: a research review to inspire future study

K Bi, Y Chen, S Zhao, Y Kuang… - BioMed research …, 2018 - Wiley Online Library
Visceral leishmaniasis (VL), one of the deadliest parasitic diseases in the world, causes
more than 50,000 human deaths each year and afflicts millions of people throughout South …

Leishmania vaccines entered in clinical trials: a review of literature

M Moafi, H Rezvan, R Sherkat… - International Journal of …, 2019 - journals.lww.com
Leishmaniasis is considered as a zoonotic infection and neglected tropical disease.
Leishmania treatment is not totally successful and imposes high expenditures, especially in …

A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

F Oliveira, E Rowton, H Aslan, R Gomes… - Science translational …, 2015 - science.org
Currently, there are no commercially available human vaccines against leishmaniasis. In
rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection …

Leishmaniasis and various immunotherapeutic approaches

Y Taslimi, F Zahedifard, S Rafati - Parasitology, 2018 - cambridge.org
Leishmaniasis is a vector-borne infectious disease caused by multiple Leishmania (L.)
species with diverse clinical manifestations. There is currently no vaccine against any form …

Nanotechnology-based strategies in parasitic disease management: from prevention to diagnosis and treatment

R Tiwari, RP Gupta, VK Singh, A Kumar, Rajneesh… - ACS …, 2023 - ACS Publications
Parasitic infections are a major global health issue causing significant mortality and
morbidity. Despite substantial advances in the diagnostics and treatment of these diseases …

Immunotherapy and immunochemotherapy in combating visceral leishmaniasis

G Yadagiri, A Singh, K Arora, SL Mudavath - Frontiers in Medicine, 2023 - frontiersin.org
Visceral leishmaniasis (VL), a vector-borne disease, is caused by an obligate
intramacrophage, kinetoplastid protozoan parasite of the genus Leishmania. Globally, VL is …

In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani

S Saha, S Vashishtha, B Kundu, M Ghosh - BMC bioinformatics, 2022 - Springer
Abstract Background Visceral Leishmaniasis (VL) is a fatal vector-borne parasitic disorder
occurring mainly in tropical and subtropical regions. VL falls under the category of neglected …

[HTML][HTML] A large-scale field randomized trial demonstrates safety and efficacy of the vaccine LetiFend® against canine leishmaniosis

JF Cotrina, V Iniesta, I Monroy, V Baz, C Hugnet… - Vaccine, 2018 - Elsevier
Canine leishmaniosis is a zoonotic disease caused by Leishmania infantum. Extensive
research is currently ongoing to develop safe and effective vaccines to protect from disease …