Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Cancer cells accumulate genetic and epigenetic changes that alter gene expression to drive
tumorigenesis. Epigenetic silencing of tumor suppressor, cell cycle, differentiation and DNA …

Gene expression is regulated by a number of interrelated posttranslational modifications of
histones, including citrullination. For example, peptidylarginine deminase 4 (PAD4) converts …

Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in
malignant transformation. We investigated the clinical significance of miR-650 and its …

Abstract ING genes (ING1–5) were identified has tumor suppressor genes. ING proteins are
characterized as Type II TSGs since they are involved in the control of cell proliferation …

Growing evidence has suggested that inhibitor of growth 4 (ING4), a novel member of ING
family proteins, plays a critical role in the development and progression of different tumors …

Gene therapy is a rapidly emerging remedial route for many serious incurable diseases,
such as central nervous system (CNS) diseases. Currently, nucleic acid medicines …

Abstract Inhibitor of growth 4 (ING4), a member of the ING family discovered in 2003, has
been shown to act as a tumor suppressor and is frequently down-regulated in various …

Abstract Inhibitor of growth 4 (ING4), a member of the conserved ING family, has been
identified as an important tumor suppressor since it plays a critical role in the regulation of …

There is growing evidence that inhibitor of growth 4 (ING4) plays a pivotal role in
development and progression of multiple different tumors; however, its precise function in …