Caffeine and Parkinson's disease: multiple benefits and emerging mechanisms

X Ren, JF Chen - Frontiers in Neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder,
characterized by dopaminergic neurodegeneration, motor impairment and non-motor …

Neurotoxicity of MDMA: Main effects and mechanisms

G Costa, K Gołembiowska - Experimental neurology, 2022 - Elsevier
Preclinical and clinical studies indicate that 3, 4-methylenedioxymethamphetamine
(MDMA;'ecstasy'), in addition to having abuse potential, may elicit acute and persistent …

[HTML][HTML] Neurodegenerative diseases: Can caffeine be a powerful ally to weaken neuroinflammation?

M Ruggiero, R Calvello, C Porro, G Messina… - International journal of …, 2022 - mdpi.com
In recent years, there has been considerable research showing that coffee consumption
seems to be beneficial to human health, as it contains a mixture of different bioactive …

[HTML][HTML] Do caffeine and more selective adenosine A2A receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?

JF Chen, MA Schwarzschild - Parkinsonism & related disorders, 2020 - Elsevier
The adenosine A 2A receptor is a major target of caffeine, the most widely used
psychoactive substance worldwide. Large epidemiological studies have long shown …

[HTML][HTML] Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice

G Costa, M Serra, R Maccioni, MA Casu… - Biomedicine & …, 2023 - Elsevier
Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral
beneficial properties. Several studies have accrued indicating that the recreational …

The impact of psychostimulants on central and peripheral neuro-immune regulation: a sco** review of cytokine profiles and their implications for addiction

J Bravo, C Magalhães, EB Andrade… - Frontiers in Cellular …, 2023 - frontiersin.org
It is now well-accepted that psychostimulants act on glial cells causing neuroinflammation
and adding to the neurotoxic effects of such substances. Neuroinflammation can be …

Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings

M Serra, N Simola, AE Pollack… - Neural Regeneration …, 2024 - journals.lww.com
Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse
potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by …

Caffeine-based food supplements and beverages: Trends of consumption for performance purposes and safety concerns

SMF Bessada, RC Alves, MBPP Oliveira - Food Research International, 2018 - Elsevier
Nowadays, daily food supplementation regarding the improvement of physical and mental
performance is a growing trend in sport practitioners, young students and active people …

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies

G Costa, MA De Luca, G Piras, J Marongiu… - Neural regeneration …, 2020 - journals.lww.com
Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to
having abuse potential, may elicit toxic effects of varying severity at the peripheral and …

Neuroinflammation and L-dopa-induced abnormal involuntary movements in 6-hydroxydopamine-lesioned rat model of Parkinson's disease are counteracted by …

A Pinna, G Costa, M Serra, L Contu, M Morelli - Neuropharmacology, 2021 - Elsevier
Several lines of evidence have strongly implicated neuroinflammation in Parkinson's
disease (PD) progression and l-dopa-induced dyskinesia. The present study investigated …