Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Angiogenesis is the process of generating new blood vessels from pre-existing vasculature.
Under normal conditions, this process is delicately controlled by pro-angiogenic and anti …

Thalidomide, lenalidomide and pomalidomide are immunomodulatory drugs (IMiDs)
effective in the treatment of multiple myeloma, myelodysplastic syndrome (MDS) with …

Simple Summary Treatments for coronavirus disease-2019 (COVID-19) have utilized a
variety of medications, including antivirals, immunomodulators, and other therapeutics such …

Modern drug design aims to discover novel lead compounds with attractable chemical
profiles to enable further exploration of the intersection of chemical space and biological …

Immunomodulatory medications like thalidomide and its analogs prevent the production of
some proinflammatory cytokines linked to cancer. A new series of thalidomide analogs were …

Many drugs are chiral with their chirality determining their biological interactions, safety, and
efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer …

Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder. The
anti–interleukin 6 (IL-6) therapy siltuximab is not available everywhere, and is not effective …