Membrane proteins play key roles in human health, contributing to cellular signaling, ATP
synthesis, immunity, and metabolite transport. Protein folding is the pivotal early step for their …

Intracellular membranes composing organelles of eukaryotes include membrane proteins
playing crucial roles in physiological functions. However, a comprehensive understanding of …

Oxidative modifications can disrupt protein folds and functions, and are strongly associated
with human aging and diseases. Conventional oxidation pathways typically involve the free …

Transmembrane transporter proteins are essential for maintaining cellular homeostasis and,
as such, are key drug targets. Many transmembrane transporter proteins are known to …

Single-molecule magnetic tweezers have recently been adapted for monitoring the
interactions between transmembrane helices of membrane proteins within lipid bilayers. In …

Molecular tethering of a single membrane protein between the glass surface and a magnetic
bead is essential for studying the structural dynamics of membrane proteins using magnetic …

In this issue of Structure, Blaimschein et al. elucidate the chaperoning function of the
insertase YidC during the insertion and folding of the melibiose permease MelB. Their single …

Polyethylene glycol (PEG) is an artificial polymer with good biocompatibility and a low cost,
which has a wide range of applications. In this study, the dynamic response of PEG single …

The nucleus, which plays crucial roles in regulating life activities, is the largest and stiffest
organelle in the cell and serves as the center of genetic information storage, replication, and …

Dimerization of transmembrane (TM) proteins is an essential biological process within
cellular membranes, playing a key role in diverse pathophysiological pathways and serving …