Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review
Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …
imaging (MRI) biomarker for investigating brain function and composition. This …
[HTML][HTML] Fluid biomarkers for the diagnosis of neurodegenerative diseases
M Luebke, M Parulekar, FP Thomas - Biomarkers in Neuropsychiatry, 2023 - Elsevier
In this review, we evaluate the role of fluid biomarkers related to neurodegenerative
diseases. Such conditions present diagnostic challenges due to phenotypic heterogeneity …
diseases. Such conditions present diagnostic challenges due to phenotypic heterogeneity …
C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …
neurite density and dispersion through computation of the neurite density index (NDI) and …
[HTML][HTML] Association of plasma markers of Alzheimer's disease, neurodegeneration, and neuroinflammation with the choroid plexus integrity in aging
The choroid plexus (CP) is a vital brain structure essential for cerebrospinal fluid (CSF)
production. Moreover, alterations in the CP's structure and function are implicated in …
production. Moreover, alterations in the CP's structure and function are implicated in …
Hypertensive adults exhibit lower myelin content: a multicomponent relaxometry and diffusion magnetic resonance imaging study
BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination.
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
KA Walker, Y An, A Moghekar, R Moaddel… - Molecular …, 2024 - Springer
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for
late onset Alzheimer's disease (AD). This case-cohort study used targeted plasma …
late onset Alzheimer's disease (AD). This case-cohort study used targeted plasma …
In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal …
DM Niedowicz, Y Katsumata… - … of Neuropathology & …, 2023 - academic.oup.com
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and hippocampal sclerosis of aging (HS-A) pathologies are found together at autopsy …
NC) and hippocampal sclerosis of aging (HS-A) pathologies are found together at autopsy …
Alzheimer's disease-related phospho-Tau181 signals are localized to demyelinated axons of parvalbumin-positive GABAergic interneurons in an App knock-in mouse …
Y Hirota, Y Sakakibara, K Takei… - Journal of …, 2023 - content.iospress.com
Background: The tau protein phosphorylated at Thr181 (p-tau181) in cerebrospinal fluid and
blood is a sensitive biomarker for Alzheimer's disease (AD). Increased p-tau181 levels …
blood is a sensitive biomarker for Alzheimer's disease (AD). Increased p-tau181 levels …
[HTML][HTML] REUSED: A deep neural network method for rapid whole-brain high-resolution myelin water fraction map** from extremely under-sampled MRI
Abstract Changes in myelination are a cardinal feature of brain development and the
pathophysiology of several central nervous system diseases, including multiple sclerosis …
pathophysiology of several central nervous system diseases, including multiple sclerosis …
Relationship between sleep, physical fitness, brain microstructure, and cognition in healthy older adults: A pilot study
Background There is a critical need for neuroimaging markers of brain integrity to monitor
effects of modifiable lifestyle factors on brain health. This observational, cross-sectional …
effects of modifiable lifestyle factors on brain health. This observational, cross-sectional …