Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Neurobiologists have long sought to understand how circuits in the nervous system are
organized to generate the precise neural outputs that underlie particular behaviours. The …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Eph receptors constitute the largest family of tyrosine kinase receptors and, together with
their plasma-membrane-bound ephrin ligands, have many important functions during …

Intrinsic spinal networks, known as central pattern generators (CPGs), control the timing and
pattern of the muscle activity underlying locomotion in mammals. This review discusses new …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor
neurons. Disease onset and progression are variable, with survival ranging from months to …

Structural variations (SVs) contribute to the variability of our genome and are often
associated with disease. Their study in model systems was hampered until now by labor …

The sequential step** of left and right limbs is a fundamental motor behavior that
underlies walking movements. This relatively simple locomotor behavior is generated by the …

The control of cell movement during development is essential for forming and stabilizing the
spatial organization of tissues and cell types. During initial steps of tissue patterning, distinct …