The pathogenic basis of malaria

LH Miller, DI Baruch, K Marsh, OK Doumbo - Nature, 2002 - nature.com
Malaria is today a disease of poverty and underdeveloped countries. In Africa, mortality
remains high because there is limited access to treatment in the villages. We should follow …

Oxidative stress in malaria parasite-infected erythrocytes: host–parasite interactions

K Becker, L Tilley, JL Vennerstrom, D Roberts… - International journal for …, 2004 - Elsevier
Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …

Malaria in pregnancy: pathogenesis and immunity

SJ Rogerson, L Hviid, PE Duffy, RFG Leke… - The Lancet infectious …, 2007 - thelancet.com
Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …

Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa

HL Guyatt, RW Snow - Clinical microbiology reviews, 2004 - Am Soc Microbiol
Malaria during pregnancy can result in low birth weight (LBW), an important risk factor for
infant mortality. This article reviews the pathological effects of malaria during pregnancy and …

PTEX is an essential nexus for protein export in malaria parasites

B Elsworth, K Matthews, CQ Nie, M Kalanon… - Nature, 2014 - nature.com
During the blood stages of malaria, several hundred parasite-encoded proteins are exported
beyond the double-membrane barrier that separates the parasite from the host cell …

Malaria− an overview

R Tuteja - The FEBS journal, 2007 - Wiley Online Library
Malaria is caused by protozoan parasites of the genus Plasmodium and is a major cause of
mortality and morbidity worldwide. These parasites have a complex life cycle in their …

Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

FHA Osier, G Feng, MJ Boyle, C Langer, J Zhou… - BMC medicine, 2014 - Springer
Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …

Malaria during pregnancy

M Fried, PE Duffy - Cold Spring Harbor …, 2017 - perspectivesinmedicine.cshlp.org
One hundred and twenty-five million women in malaria-endemic areas become pregnant
each year (see Dellicour et al. PLoS Med 7: e1000221 [2010]) and require protection from …

Clinical features and pathogenesis of severe malaria

CL Mackintosh, JG Beeson, K Marsh - Trends in parasitology, 2004 - cell.com
A major change in recent years has been the recognition that severe malaria, predominantly
caused by Plasmodium falciparum, is a complex multi-system disorder presenting with a …

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

MJ Boyle, DW Wilson, JS Richards… - Proceedings of the …, 2010 - National Acad Sciences
During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs. Currently
there is limited knowledge of cellular and molecular invasion events, and no established …