Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …

The dominant risk factors for late-onset Alzheimer's disease (AD) are advanced age and the
APOE4 genetic variant. To examine how these factors alter neuroimmune function, we …

Recent genetic studies on Alzheimer's disease (AD) have brought microglia under the
spotlight, as loci associated with AD risk are enriched in genes expressed in microglia …

Microglia are innate immune cells in the brain. Transcription factor IRF8 (interferon
regulatory factor 8) is highly expressed in microglia. However, its role in postnatal microglia …

Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus
(PVN) plays a key role in regulating body weight and blood glucose levels. However, it is …

The brain's primary immune cells, microglia, are a leading causal cell type in Alzheimer's
disease (AD). Yet, the mechanisms by which microglia can drive neurodegeneration remain …

There are several cellular and acellular structural barriers associated with the brain
interfaces, which include the dura, the leptomeninges, the perivascular space and the …