The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Mutations in the CACNA1A gene that encodes the pore-forming α 1 subunit of human
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channels cause several autosomal-dominant …

Familial hemiplegic migraine (FHM) is a rare and genetically heterogeneous autosomal
dominant subtype of migraine with aura. Mutations in the genes CACNA1A and SCNA1A …

Inflammation is a major characteristic of envenomation by snakes from viperine and
crotaline species. Bothrops asper snake venom elicits, among other alterations, a …

Voltage-gated calcium channels (VGCC) play obligatory physiological roles, including
modulation of neuronal functions, synaptic plasticity, neurotransmitter release and gene …

Missense mutations in CACNA1A, the gene that encodes the pore-forming α1 subunit of
human voltage-gated CaV2. 1 (P/Q-type) calcium channels, cause a rare form of migraine …

Chronic pain is a major therapeutic problem as the current treatment options are
unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels …

Nerve growth factor (NGF) is involved in pain transduction mechanisms and plays a key role
in many persistent pain states, notably those associated with inflammation. On this basis …

Pain remains a major clinical challenge, severely afflicting around 6% of the population at
any one time. Channelopathies that underlie monogenic human pain syndromes are of …

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the
discovery of their relation to pain processing control, they are investigated to find new …