Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

The increase of Angiontesin-II (Ang-II), one of the key peptides of the renin-angiotensin
system (RAS), and its binding to the Ang-II type 1 receptor (AT1R) during hypertension is a …

CD8+ T cell immune responses are regulated by multi-layer networks, while the post-
translational regulation remains largely unknown. Transmembrane ectodomain shedding is …

Background Traumatic brain injury (TBI) remains one of the main causes for disability and
death worldwide. While the primary mechanical injury cannot be avoided, the prevention of …

Cell surface metalloproteases coordinate signaling during development, tissue
homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (" …

Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an
important mechanism of regulating intercellular signalling. TACE is a major shedding …

Redox-mediated signal transduction depends on the enzymatic production of second
messengers such as hydrogen peroxide, nitric oxide and hydrogen sulfite, as well as …

In contrast to many other signalling mechanisms shedding of membrane-anchored proteins
is an irreversible process. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the …

Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is
enabled by its remarkable capacity to systematically subvert host immune defenses. In …

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …