The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …

The nasal route has been investigated as a promising alternative for drug delivery to the
central nervous system, avoiding passage through the blood–brain barrier and improving …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

Abstract Evaluation of the regional intranasal delivery of locally acting drugs in children is
challenging. Anatomical nasal airway replicas potentially can provide a robust pre-clinical …

In this work we present the development of in situ gelling nanosuspension as advanced form
for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling …

Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …

Computational fluid dynamics (CFD) has been used to investigate the intranasal deposition
of corticosteroid sprays. CFD Lagrangian tracking models terminate particle motion once …

In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …

Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …