Oxygen Activation and Energy Conservation by Cytochrome c Oxidase

M Wikström, K Krab, V Sharma - Chemical reviews, 2018 - ACS Publications
This review focuses on the type A cytochrome c oxidases (C c O), which are found in all
mitochondria and also in several aerobic bacteria. C c O catalyzes the respiratory reduction …

New perspectives on proton pum** in cellular respiration

M Wikstrom, V Sharma, VRI Kaila, JP Hosler… - Chemical …, 2015 - ACS Publications
Cellular respiration has a long research history at the interface between biology, chemistry,
and physics. Research in this field spans the entire range from fundamental mechanistic and …

[HTML][HTML] The superfamily of heme–copper oxygen reductases: types and evolutionary considerations

FL Sousa, RJ Alves, MA Ribeiro, JB Pereira-Leal… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Heme–copper oxygen reductases (HCO) reduce O2 to water being the last enzymatic
complexes of most aerobic respiratory chains. These enzymes promote energy conservation …

[HTML][HTML] Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases

M Wikström, MI Verkhovsky - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
Recent time-resolved optical and electrometric experiments have provided a sequence of
events for the proton-translocating mechanism of cytochrome c oxidase. These data also set …

Diversity of the heme–copper superfamily in archaea: insights from genomics and structural modeling

J Hemp, RB Gennis - Bioenergetics: Energy Conservation and …, 2008 - Springer
Recent advances in DNA sequencing technologies have provided unprecedented access
into the diversity of the microbial world. Herein we use the comparative genomic analysis of …

Role of water and protein dynamics in proton pum** by respiratory complex I

O Haapanen, V Sharma - Scientific reports, 2017 - nature.com
Membrane bound respiratory complex I is the key enzyme in the respiratory chains of
bacteria and mitochondria, and couples the reduction of quinone to the pum** of protons …

[HTML][HTML] The identity of the transient proton loading site of the proton-pum** mechanism of cytochrome c oxidase

VRI Kaila, V Sharma, M Wikström - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Cellular respiration is driven by cytochrome c oxidase (CcO), which reduces oxygen to water
and couples the released energy to proton pum** across the mitochondrial or bacterial …

[HTML][HTML] Looking for the minimum common denominator in haem–copper oxygen reductases: Towards a unified catalytic mechanism

MM Pereira, FL Sousa, AF Veríssimo… - Biochimica et Biophysica …, 2008 - Elsevier
Haem–copper oxygen reductases are transmembrane protein complexes that reduce
dioxygen to water and pump protons across the mitochondrial or periplasmatic membrane …

Insights into functions of the H channel of cytochrome c oxidase from atomistic molecular dynamics simulations

V Sharma, PG Jambrina, M Kaukonen… - Proceedings of the …, 2017 - National Acad Sciences
Proton pum** A-type cytochrome c oxidase (C c O) terminates the respiratory chains of
mitochondria and many bacteria. Three possible proton transfer pathways (D, K, and H …