Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Anticancer drug discovery from microbial sources: The unique mangrove streptomycetes
Worldwide cancer incidence and mortality have always been a concern to the community.
The cancer mortality rate has generally declined over the years; however, there is still an …
The cancer mortality rate has generally declined over the years; however, there is still an …
A human functional protein interaction network and its application to cancer data analysis
Background One challenge facing biologists is to tease out useful information from massive
data sets for further analysis. A pathway-based analysis may shed light by projecting …
data sets for further analysis. A pathway-based analysis may shed light by projecting …
Algorithms for detecting significantly mutated pathways in cancer
Recent genome sequencing studies have shown that the somatic mutations that drive
cancer development are distributed across a large number of genes. This mutational …
cancer development are distributed across a large number of genes. This mutational …
Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes
H Shi, J Xu, G Zhang, L Xu, C Li, L Wang, Z Zhao… - BMC systems …, 2013 - Springer
Background MicroRNAs (miRNAs) are important post-transcriptional regulators that have
been demonstrated to play an important role in human diseases. Elucidating the …
been demonstrated to play an important role in human diseases. Elucidating the …
Predictive genomics: a cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data
E Wang, N Zaman, S Mcgee, JS Milanese… - Seminars in cancer …, 2015 - Elsevier
Tumor genome sequencing leads to documenting thousands of DNA mutations and other
genomic alterations. At present, these data cannot be analyzed adequately to aid in the …
genomic alterations. At present, these data cannot be analyzed adequately to aid in the …
Separate enrichment analysis of pathways for up-and downregulated genes
Two strategies are often adopted for enrichment analysis of pathways: the analysis of all
differentially expressed (DE) genes together or the analysis of up-and downregulated genes …
differentially expressed (DE) genes together or the analysis of up-and downregulated genes …
Differential network entropy reveals cancer system hallmarks
The cellular phenotype is described by a complex network of molecular interactions.
Elucidating network properties that distinguish disease from the healthy cellular state is …
Elucidating network properties that distinguish disease from the healthy cellular state is …
DrugComboRanker: drug combination discovery based on target network analysis
Motivation: Currently there are no curative anticancer drugs, and drug resistance is often
acquired after drug treatment. One of the reasons is that cancers are complex diseases …
acquired after drug treatment. One of the reasons is that cancers are complex diseases …
Critical transition and reversion of tumorigenesis
D Shin, KH Cho - Experimental & Molecular Medicine, 2023 - nature.com
Cancer is caused by the accumulation of genetic alterations and therefore has been
historically considered to be irreversible. Intriguingly, several studies have reported that …
historically considered to be irreversible. Intriguingly, several studies have reported that …