The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Asthma is a chronic airway disease, which affects more than 300 million people. The
pathogenesis of asthma exhibits marked heterogeneity with many phenotypes defining …

Chronic exposure to environmental pollutants is a major contributor to the development and
progression of obstructive airway diseases, including asthma and COPD. Understanding the …

Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …

Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …

Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to
determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from …

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are
implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL …

Asthma and obesity are two epidemics affecting the developed world. The relationship
between obesity and both asthma and severe asthma appears to be weight-dependent …

Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …

Inflammation, structural, and functional abnormalities within the airways are key features of
asthma. Although these processes are well documented, their expression varies across the …