Migraine affects more than one billion individuals each year across the world, and is one of
the most common neurologic disorders, with a high prevalence and morbidity, especially …

The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …

The terminology “gut-brain axis “points out a bidirectional relationship between the GI
system and the central nervous system (CNS). To date, several researches have shown that …

Migraine is characterized by recurrent attacks of disabling headaches, often accompanied
by sensory and motor disturbances. Clinical manifestations of migraine are influenced by …

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a
prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies …

Several lines of evidence support a role of the immune system in headache pathogenesis,
with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte …

Migraine is a common headache with a large negative impact on health. Several
endogenous and exogenous factors can influence the severity and frequency of migraine …

Migraine is a painful neurological condition characterized by severe pain on one or both
sides of the head. It may be linked to changes in the gut microbiota, which are influenced by …

The rapidly advancing field of digital health technologies provides a great opportunity to
radically transform the way clinical trials are conducted and to shift the clinical trial paradigm …

An increasing amount of evidence suggests that migraines are a response to a cerebral
energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic …