[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Inflammation and cancer: triggers, mechanisms, and consequences
FR Greten, SI Grivennikov - Immunity, 2019 - cell.com
Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …
Cancer progression and the invisible phase of metastatic colonization
CA Klein - Nature Reviews Cancer, 2020 - nature.com
Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …
Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis
Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
The dark side of fibroblasts: cancer-associated fibroblasts as mediators of immunosuppression in the tumor microenvironment
L Monteran, N Erez - Frontiers in immunology, 2019 - frontiersin.org
Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …
most types of solid tumors, and were shown to facilitate cancer progression by supporting …
Cellular senescence in brain aging
E Sikora, A Bielak-Zmijewska, M Dudkowska… - Frontiers in aging …, 2021 - frontiersin.org
Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases
L Cuollo, F Antonangeli, A Santoni, A Soriani - Biology, 2020 - mdpi.com
Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …
Senescent cell clearance by the immune system: Emerging therapeutic opportunities
Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …
Aging of the cells: Insight into cellular senescence and detection Methods
Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …