[HTML][HTML] The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders

E Knezevic, K Nenic, V Milanovic, NN Knezevic - Cells, 2023 - mdpi.com
Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal
role in various physiological processes. Its release is finely orchestrated by the …

Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

B Guo, M Zhang, W Hao, Y Wang, T Zhang… - Translational …, 2023 - nature.com
Mood disorders are associated with elevated inflammation, and the reduction of symptoms
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …

[HTML][HTML] Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

The menace of obesity to depression and anxiety prevalence

S Fulton, L Décarie-Spain, X Fioramonti… - Trends in Endocrinology …, 2022 - cell.com
The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

New and emerging approaches to treat psychiatric disorders

KW Scangos, MW State, AH Miller, JT Baker… - Nature medicine, 2023 - nature.com
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Immune targets for therapeutic development in depression: towards precision medicine

WC Drevets, GM Wittenberg, ET Bullmore… - Nature reviews Drug …, 2022 - nature.com
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

[HTML][HTML] Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology

DR Goldsmith, M Bekhbat, ND Mehta, JC Felger - Biological psychiatry, 2023 - Elsevier
Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

[HTML][HTML] Diet, stress and mental health

JD Bremner, K Moazzami, MT Wittbrodt, JA Nye… - Nutrients, 2020 - mdpi.com
Introduction: There has long been an interest in the effects of diet on mental health, and the
interaction of the two with stress; however, the nature of these relationships is not well …

The role of the immune system in posttraumatic stress disorder

S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …

Stress, sex hormones, inflammation, and major depressive disorder: Extending Social Signal Transduction Theory of Depression to account for sex differences in …

GM Slavich, J Sacher - Psychopharmacology, 2019 - Springer
Abstract Social Signal Transduction Theory of Depression is a biologically plausible, multi-
level theory that describes neural, physiologic, molecular, and genomic mechanisms that …