During vertebrate development, cells must proliferate, move, and differentiate to form
complex shapes. Elucidating the mechanisms underlying the molecular and cellular …

The structural development of the heart depends heavily on mechanical forces, and rhythmic
contractions generate essential physical stimuli during morphogenesis. Cardiac cells play a …

Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to
their mechanical environment through mechanosensitive pathways. How mechanical cues …

Clinically serious congenital heart valve defects arise from improper growth and remodeling
of endocardial cushions into leaflets. Genetic mutations have been extensively studied but …

The formation and organization of complex blood vessel networks rely on various
biophysical forces, yet the mechanisms governing endothelial cell-cell interactions under …

De novo lumen formation necessitates the precise segregation of junctional proteins from
apical surfaces, yet the underlying mechanisms remain unclear. Using a zebrafish model …

Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …

The emergence of human-induced Pluripotent Stem Cells (hiPSCs) has dramatically
improved our understanding of human developmental processes under normal and …

Dynamic imaging of the beating embryonic heart in 3D is critical for understanding cardiac
development and defects. Optical coherence tomography (OCT) plays an important role in …

During early embryonic development, the heart undergoes a remarkable and complex
transformation, acquiring its iconic four-chamber structure whilst concomitantly contracting to …