T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

The success of targeted therapies and immunotherapies has created optimism that cancers
may be curable. However, not all patients respond, drug resistance is common and many …

Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Cell–cell communications in multicellular organisms generally involve secreted ligand–
receptor (LR) interactions, which is vital for various biological phenomena. Recent …

Single-cell sequencing technologies can be used to detect the genome, transcriptome and
other multi-omics of single cells. They can show the differences and evolutionary …

Objective Hepatocellular carcinoma (HCC) represents a typical inflammation-associated
cancer. Tissue resident innate lymphoid cells (ILCs) have been suggested to control tumour …

Single-cell RNA sequencing (scRNA-seq) data are noisy and sparse. Here, we show that
transfer learning across datasets remarkably improves data quality. By coupling a deep …

Single cell analysis has become of great interest with unprecedented capabilities for the
systematic investigation of cell-to-cell variation in large populations. Rapid and multi …

The era of targeted therapies has seen significant improvements in depth of response,
progression-free survival, and overall survival for patients with multiple myeloma. Despite …