Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut

Y Zhang, R Hao, J Chen, S Li, K Huang… - Critical Reviews in …, 2024 - Taylor & Francis
Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely
found in plants and some marine organisms. Due to the complexity of the structure of …

Ginsenoside Rg1 prevent and treat inflammatory diseases: A review

Y Gao, J Li, J Wang, X Li, J Li, S Chu, L Li… - International …, 2020 - Elsevier
Ginseng has been used as reinforcing drugs or for traditional Chinese medicine in aging,
inflammation, stress, diabetes mellitus, hepatic diseases and cancer. The aim of this current …

Processing technologies, phytochemistry, bioactivities and applications of black ginseng-a novel manufactured ginseng product: A comprehensive review

L Huang, HJ Li, YC Wu - Food Chemistry, 2023 - Elsevier
Black ginseng is a novel manufactured ginseng product, and the application of black
ginseng products in market is increasing in recent years. Black ginseng is prepared by …

The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities

JN del Hierro, T Herrera, T Fornari, G Reglero… - Journal of Functional …, 2018 - Elsevier
Saponins are bioactive compounds of increasing interest. The events that take place during
digestion are highly related to their bioactivities, because saponins are poorly absorbed and …

Ginsenoside Rb1 protects against diabetes-associated metabolic disorders in Kkay mice by resha** gut microbiota and fecal metabolic profiles

R Zhou, D He, H Zhang, J **e, S Zhang, X Tian… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Panax quinquefolius Linn. is one of the most
valuable herbal medicine in the world for its broad health benefits, including anti-diabetes …

Ginsenoside Rb1 improves metabolic disorder in high-fat diet-induced obese mice associated with modulation of gut microbiota

H Zou, M Zhang, X Zhu, L Zhu, S Chen, M Luo… - Frontiers in …, 2022 - frontiersin.org
Gut microbiota plays an important role in metabolic homeostasis. Previous studies
demonstrated that ginsenoside Rb1 might improve obesity-induced metabolic disorders …

Hepataprotective effects of ginsenoside Rg1–A review

Y Gao, S Chu, Z Zhang, N Chen - Journal of Ethnopharmacology, 2017 - Elsevier
Background and ethnopharmacological relevance Ginseng has been used as efficient tonic
and for the treatment of various diseases including hepatic disorders. Ginseng saponins …

Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial …

H Shen, XJ Gao, T Li, WH **g, BL Han, YM Jia… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Polysaccharides and small molecules commonly co-exist
in decoctions of traditional Chinese medicines (TCMs). Our previous study outlined that …

[HTML][HTML] Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human …

MK Choi, S **, JH Jeon, WY Kang, SJ Seong… - Journal of Ginseng …, 2020 - Elsevier
Background We investigated the tolerability and pharmacokinetic properties of various
ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple …

Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats

Y Chen, K Zhang, H Liu, Y Zhu, Q Bu, S Song, Y Li… - Scientific Reports, 2024 - nature.com
Ginsenoside Rb1 exhibits a wide range of biological activities, and gut microbiota is
considered the main metabolic site for Rb1. However, the impact of gut microbiota on the …