Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Twenty-five years ago, Hancock and Parks asked a provocative question:“what is the true
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …

The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel
carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral …

As a promising strategy, amorphous solid dispersion has been extensively employed in
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …

Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

The excipients present in an amorphous solid dispersion (ASD) are essential functional
additives that ultimately influence the drug release performance and absorption. Herein, the …

Amorphization is one of the most effective pharmaceutical approaches to enhance the
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …

The formation of crystalline materials typically follows the nucleation and crystal growth
pathway, which enables scientists to engineer crystal properties, and the metastable status …

The polymer used in an amorphous solid dispersion (ASD) formulation plays a critical role in
dosage form performance. Herein, drug–polymer interactions in aqueous solution were …

The use of an amorphous drugs system to generate supersaturated solutions is generally
developed to improve the solubility and dissolution of poorly soluble drugs. This is because …