The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has
been limited both in numbers and geographically, and the evidence base has been confined …

The placenta is a critical organ during pregnancy, essential for the provision of an optimal
intrauterine environment, with fetal survival, growth, and development relying on correct …

Objective This document purpose is to create an evidence-based position statement on the
role of metformin therapy in pregnancy complicated by obesity, gestational diabetes (GDM) …

Metformin use in pregnancy is increasing worldwide as randomised controlled trial (RCT)
evidence is emerging demonstrating its safety and efficacy. The Metformin in Gestational …

Membrane transporters play critical roles in moving a variety of anticancer drugs across
cancer cell membrane, thereby determining chemotherapy efficacy and/or toxicity. The …

Background Gestational disorders such as intrauterine growth restriction (IUGR) and pre-
eclampsia (PE) are main causes of poor perinatal outcomes worldwide. Both diseases are …

The placenta serves as the interface between the maternal and fetal circulations and
regulates the transfer of oxygen, nutrients, and waste products. When exogenous …

Abstract Serotonin [5-hydroxytryptamine (5-HT)] is essential to intrauterine development, but
its source is debated. We used immunocytochemistry to gauge 5-HT, its biosynthetic enzyme …

Tremendous efforts have been directed to investigate the ontogeny of drug transporters in
fetuses, neonates, infants, and children based on their importance for understanding drug …