Pathogenic microorganisms are causative agents for different types of serious and even
lethal infectious diseases. Despite advancements in medication, bacterial and fungal …

During recent years, small molecules containing five-member heterocyclic moieties have
become the subject of considerable growing interest for designing new antitumor agents …

We designed and synthesized the 1, 3, 4-thiadiazole derivatives differing in the structure of
the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds …

Background: Bacterial infections are a growing problem worldwide causing morbidity and
mortality mainly in develo** countries. Moreover, the increased number of …

The 1, 3, 4-thiadiazole nucleus has attracted the attention of medicinal chemists during the
last decades due to its multiple pharmacological activities, such as antiviral, anticancer …

The 1, 2, 3-thiadiazole moiety occupies a significant and prominent position among
privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics …

Various studies showed adenosine A 2 A receptors (A 2 ARs) antagonists have profound
therapeutic efficacy in Parkinsons Disease (PD) by improving dopamine transmission, thus …

Bacterial resistance associated to different antibiotics is a limitation for the treatment of
infections and this has stimulated the development of new antimicrobial agents. In this …

The study of the chemical and biological properties of molecules simultaneously comprising
various heterocycles, such as fused 1, 3, 4–oxadiazolyl–1, 2, 3–triazoles and 1, 2, 4–triazolyl …

Thiadiazole derivatives, a class of compounds with significant biological applications, are
extensively explored in medicinal chemistry. The synthesis section covers various methods …