An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

I Ahmad - MedChemComm, 2017 - pubs.rsc.org
Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic
drugs are available on the market, and several compounds are in different phases of clinical …

Medicinal chemistry of quinazolines as anticancer agents targeting tyrosine kinases

MF Zayed - Scientia Pharmaceutica, 2023 - mdpi.com
Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …

Design, synthesis, characterization, enzymatic inhibition evaluations, and docking study of novel quinazolinone derivatives

K Pedrood, M Sherafati… - International Journal of …, 2021 - Elsevier
In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against
metabolic enzymes including α-glycosidase, acetylcholinesterase, butyrylcholinesterase …

Synthesis, characterization, in vitro antimicrobial and cytotoxic evaluation of Co (II), Ni (II), Cu (II) and Zn (II) complexes derived from bidentate hydrazones

J Devi, S Kumar, D Kumar, DK **dal… - Research on Chemical …, 2022 - Springer
Abstract Co (II), Ni (II), Cu (II) and Zn (II) complexes have been synthesized from hydrazone
ligands (HL 1–HL 4) obtained by condensation reaction of 6-chlorothiochroman-4-one with …

Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways

M Zahedifard, F Lafta Faraj, M Paydar, C Yeng Looi… - Scientific reports, 2015 - nature.com
The current study investigated the cytotoxic effect of 3-(5-chloro-2-hydroxybenzylideneamino
)-2-(5-chloro-2-hydroxyphenyl)-2, 3-dihydroquinazolin-41 (H)-one (A) and 3-(5-nitro-2 …

Insighting the inhibitory potential of new diorganotin (IV) complexes derived from tridentate ligands: Synthesis, structural elucidation and biological evaluation

N Kumar, S Asija, Y Deswal, D Kumar, DK **dal… - Inorganic Chemistry …, 2023 - Elsevier
In the present study, a series of diorganotin (IV) complexes (1–20) with the general formula
R 2 SnL 1-4 were synthesized by the reaction of R 2 SnCl 2 (R= Me, Et, Bu, and Ph) with the …

Remarkably flexible quinazolinones—synthesis and biological applications

MM Reddy, A Sivaramakrishna - Journal of Heterocyclic …, 2020 - Wiley Online Library
Even though several quinazolinone derivatives have been synthesized, still there is a
constant demand for designing and synthesis of new quinazolinone derivatives by fine …

Development of novel ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors for tumor immunotherapy

X Wang, X Lu, D Yan, Y Zhou, X Tan - International Journal of Molecular …, 2022 - mdpi.com
The cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of
interferon genes–TANK-binding kinase 1–interferon regulating factor 3 (cGAS-STING-TBK1 …

Pentacoordinated diorganotin (IV) complexes of Schiff base ligands: synthesis, characterization, antimicrobial and anticancer studies

S Saroya, S Asija, Y Deswal, N Kumar, D Kumar… - Research on Chemical …, 2022 - Springer
In the present research work, a series of diorganotin (IV) complexes formulated as R2SnL1−
5 (where R is butyl, methyl, phenyl and L1− 5 are Schiff base ligands which were prepared …

Synthesis of benzo [4, 5] imidazo [1, 2-a] pyrimidines and 2, 3-dihydroquinazolin-4 (1 H)-ones under metal-free and solvent-free conditions for minimizing waste …

PH Tran, TPT Bui, XQB Lam, XTT Nguyen - RSC advances, 2018 - pubs.rsc.org
Brønsted acidic ionic liquid was found to be an efficient and recyclable catalyst for the
synthesis of benzo [4, 5] imidazo [1, 2-a] pyrimidines and 2, 3-dihydroquinazolin-4 (1H) …