In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

Although individual behaviors have not been proven to have a strong influence on the risk of
preterm birth, consistent evidence suggests that a constellation of favorable lifestyle factors …

Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although
dysbiosis of the gut microbiota has been implicated in chronic immune-mediated …

In both normal and pathological states, cells respond rapidly to environmental cues by
synthesizing new proteins. The selective identification of a newly synthesized proteome has …

Currently data-dependent acquisition (DDA) is the method of choice for mass spectrometry-
based proteomics discovery experiments, but data-independent acquisition (DIA) is steadily …

Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

Biomarkers enable the characterization of patient populations and quantitation of the extent
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …

G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To
identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes …

Although oxidatively damaged lipoproteins are implicated in vascular injury, there is little
information regarding the role of high-density lipoprotein (HDL) oxidation in atherogenesis …